Naxdom is a combination drug consisting of Naproxen sodium and Domperidone. It is most commonly used for the prevention of migraine attacks. The drug acts by the anti-inflammatory, analgesic, and antipyretic action of naproxen sodium (belong to the class of non-steroidal anti-inflammatory drugs), by inhibiting the release of a chemical called prostaglandin. In contrast, the combination drug domperidone acts by blocking certain dopamine receptors in the gut and the brain’s chemoreceptor zone, thereby producing antiemetic and prokinetic action ( increasing gastric motility and early emptying of the stomach).
Naxdom is available as oral tablets at a dosage of 500mg or 250 mg of Naproxen sodium and 10 mg domperidone. The drug is most commonly given as a single morning dose.
Naxdom is effective in preventing acute migraine attacks. It is also used to reduce gout-related pain, intractable vomiting, nausea, abdominal cramps, idiopathic juvenile arthritis, and osteoarthritis.
The most common side effects of naxdom are flu-like syndrome, dry mouth, and indigestion which disappears as the body adapts to the medication. However, less commonly, confusion, dizziness, rashes, and itching are observed.
1. What are the directions for use in taking a Naxdom tablet?
Naxdom should be taken as prescribed by your doctor, and the tablet can be swallowed with one glass of water. It is not advisable to skip the dose as it can decrease the effectiveness of the medication. Therefore the medication should be taken every day at a fixed time.
2. What are the contra-indications in using Naxdom?
The contra-indications include the previous history of allergy to any of the drug components or a history of allergic reaction to aspirin or ibuprofen. The drug should be avoided in patients having gastric ulcers and intestinal or stomach bleeding. It must also be avoided in patients having a history of liver or kidney disease.
3. Is Naxdom safe during pregnancy?
No, Naxdom is believed to cause fetal abnormalities and increased bleeding during pregnancy. However, there are inadequate human trials to substantiate the same.
4. Is it safe to drive while using Naxdom?
Naxdom can cause dizziness, tiredness, inadequate sleep, and blurring of vision. Therefore it is advisable to restrict your driving while taking this medication.
5. Can you consume alcohol while taking Naxdom?
No, alcohol will further worsen your headache if consumed along with Naxdom.
6. Does Naxdom cause dependency?
No, Naxdom does not cause drug dependency. However, it is advisable not to abruptly stop the medication. The medicine should be continued even after your episode of migraine and should be stopped only after taking your doctor's consultation.
7. Does Naxdom require any clinical monitoring?
Yes, long-term use of this drug can cause liver and kidney damage. Therefore your doctor may prescribe liver and kidney function tests as and when required. Concurrent use of warfarin, corticosteroids can cause an increased prevalence of gastric ulcers and bleeding.
8. Does Naxdom permanently relieve migraine?
No, Naxdom does not permanently relieve migraine. It can only prevent migraine episodes and reduce their frequency. It is advisable to take plenty of water, sound sleep. Reduce migraine trigger factors such as loud noises, consumption of chocolate, cheese, smoking, and alcohol.
9. Can we use naxdom for the long term?
No, naxdom should be taken only as per the doctor’s advice since it can cause liver and kidney damage in long-term use.
10. How long does this medicine take to act, and how long do its effects last?
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