Doripenem - Uses - Dosages - Side Effects - Precautions

Doripenem: Frequently Asked Questions Answered

What is Doripenem?

Doripenem is a synthetic broad-spectrum antibiotic belonging to the carbapenem group. It is an antibacterial drug that fights against aerobic and anaerobic as well as gram-positive and gram-negative bacteria. It is useful for treating severe stomach, urinary bladder and kidney infections. Doripenem is administered as an intravenous infusion and is generally given at hospitals. It is indicated to treat complicated bacterial infections. The medication is not useful for treating viral infections such as the common cold.

What are the uses of Doripenem?

The main uses of Doripenem include the following:

  1. Used for treating complicated intra-abdominal infections
  2. Indicated in severe urinary tract infections (UTIs)
  3. Indicated in pyelonephritis (infection to kidneys)

Doripenem must be used only to treat infections caused by susceptible bacteria. The recommended dosage is 500 mg, administered every 8 hours as an intravenous infusion over one hour in patients above 18 years of age.

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What are the side effects of Doripenem?

The main side effects of Doripenem include:

  •   Headache
  •   Diarrhoea, nausea
  •   Unusually weak or tired
  •   Itching or discharge;
  •   Mild rash, pain, swelling or redness at an injection site
  •   Allergic reactions such as skin rash, itching or hives, swelling of the face, lips or tongue
  •   Breathing problems
  •   Fever or chills, sore throat
  •   Seizures
  •   Unusual bleeding or bruising

If the side effects are severe, you should seek help from your doctor or healthcare professional as soon as possible.


Frequently Asked Questions about Doripenem

1. Is Doripenem still available?

Yes, Doripenem is available in India. However, some countries have discontinued it. If you are planning to buy this medication, make sure you are getting it from an authorised pharmacy. Check with your healthcare providers or get in touch with our experts to know the availability.

2. Is Doripenem FDA approved?

Yes, the FDA approved Doripenem in 2007 to treat severe urinary tract and abdominal infections. Recently the FDA has revised the Doripenem label and included a warning statement against the use of Doripenem in ventilator-associated pneumonia. This medication is potentially unsafe for some hospitalised patients. To know more, get in touch with our team of doctors.

3. Is Doripenem an antibiotic?

Yes, Doripenem is an antibiotic. It belongs to the carbapenem antibiotics group. Generally, Doripenem is used to treat severe bacterial infections. This antibiotic will treat only bacterial infections of the abdomen and urinary tract. It will not work against viral infections such as the common cold and flu. It is not available over the counter.

4. Can Doripenem treat UTIs?

Yes, Doripenem is useful in treating complicated UTIs caused by Escherichia coli. It is also useful for treating severe UTIs caused by concurrent bacteremia and infection of bacteria such as Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa and Acinetobacter baumannii. It is one of the highly effective antibiotics available to treat severe UTIs.

5. Does Doripenem treat pneumonia?

Recently the FDA disapproved Doripenem for treating any type of pneumonia, and the revised label also includes a new warning statement against its use in treating pneumonia. Earlier Doripenem was advised in the treatment of nosocomial pneumonia and ventilator-associated pneumonia. However, now it is not approved by the FDA.

6. Does Doripenem help with kidney problems?

Yes, Doripenem is useful for treating serious kidney infections caused by bacteria, especially Escherichia coli. When treated promptly with necessary antibiotics, you may completely recover within 2-3 weeks. Click here to get a medical opinion from an expert.

7. Does Doripenem work on Pseudomonas?

Yes, Doripenem is potent against Pseudomonas aeruginosa. Pseudomonas aeruginosa leads to severe UTIs in humans. Doripenem is effective in treating this particular infection. Consult your doctor on the choice of the best suitable medication for you.

8. Is Doripenem safe during pregnancy?

There are no adequate studies on the use of Doripenem in pregnant women. If your physician confirms that the benefits of prescribing Doripenem outweigh the risks, follow the doctor’s prescription. Kindly talk to your healthcare provider about the precautions and safety of continuing this medication.

9. Does Doripenem stop bacterial growth?

Yes, Doripenem can stop bacterial growth. Doripenem exhibits bactericidal (killing of bacteria) action against several bacterial species. It inhibits bacterial cell wall synthesis, thus leading to bacterial cell death.

10. Is Doripenem harmful?

No, Doripenem is not harmful. Some of you may experience allergic reactions. If you have a hypersensitivity reaction to carbapenems or any other allergens, please get advice from your consulting physician. Doripenem must be used only for treating bacterial infections caused by susceptible bacteria to reduce its harmful effects.

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Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.