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Cefoperazone - Uses - Dosages - Side Effects - Precautions

Cefoperazone: Frequently Asked Questions Answered

What is Cefoperazone?

Cefoperazone is a broad-spectrum semisynthetic cephalosporin that is effective against Pseudomonas infections. It is a third-generation antibiotic used to treat respiratory tract infections, peritonitis, skin infections, endometritis, and bacterial septicemia caused by susceptible organisms in the body. Cefoperazone is available under the brand name Sulperazon in some European countries.

Cefoperazone is a medication used to treat infections caused by bacteria. It works by inhibiting bacteria from creating a barrier coating necessary for their survival. Cefobid can also be used alone or in combination with other medicines.

What are the uses of Cefoperazone?

Cefoperazone is a broad-spectrum cephalosporin antibiotic used to treat bacterial infections in the respiratory system, abdomen, skin, and female genital tracts, among other organs and body locations.

It is a third-generation antibiotic used to treat respiratory tract infections, peritonitis, skin infections, endometritis, and bacterial septicemia caused by susceptible organisms in the body.

Conditions that benefit from using Cefoperazone.

  • Osteoporosis.
  • Genital disease.
  • Dermatological problems (S. aureus).
  • Pneumonia.
  • Urinary tract infection.
  • Bacterial infection (E.coli, Klebsiella spp).
  • Haemophilus infections.
  • Pseudomonas infection.
  • Pelvic Inflammatory disease.
  • Enterococcal Infections.
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What are the side effects of Cefoperazone?

Cefoperazone’s most frequent side effects include 

  • Reversible low white blood cell count.
  • Diarrhea.
  • Nausea.
  • Vomiting.
  • Discomfort.
  • Edema.
  • Redness at the injection site.

Cefoperazone can have a various adverse effects. Some are:

  • Maculopapular rash, urticaria, pruritis, anaphylaxis/angioedema, and eosinophilia are all symptoms of hypersensitivity.
  • Hypoprothrombinemia, Neutropenia, Leukopenia, and Thrombocytopenia are examples of hematologic disorders.
  • C. difficile infection, diarrhea are indications of gastrointestinal infections.
  • Interstitial nephritis is a kind of kidney disease that affects renal function.

Kindly reach out to a nearby hospital if you have uncontrolled severe side effects.

 

Frequently Asked Questions about Cefoperazone

1. Can Cefoperazone and sulbactam cause glossitis?

Yes, Cefoperazone and sulbactam are prone to cause glossitis.
Glossitis is uncommon (0.1 to 1percent). When a person develops glossitis due to an allergic response, they are more likely to develop acute glossitis, which causes rapid tongue swelling and discomfort.
If you get an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while using Cefoperazone and Sulbactam, stop taking it and seek medical attention.

2. Can Cefoperazone be given for bacterial endocarditis?

Cefoperazone is a drug that can be used for the treatment of bacterial endocarditis.
A bacterial infection of the inner layer of the heart or the heart valves is known as bacterial endocarditis.
Cefoperazone is highly effective in treating severe nosocomial infections and infectious endocarditis in hospitalized patients.

3. Can Cefoperazone be used to treat typhoid?

Yes, typhoid can be treatable with Cefoperazone.

Cefoperazone is effective in treating typhoid fever, notably when the bacteria are ampicillin or chloramphenicol-resistant. The only effective treatment for typhoid fever is antibiotic therapy.

It can also control bacterial illnesses such as pneumonia and other respiratory tract infections (lungs).

4. Is Cefoperazone safe in pregnancy?

There is no such significant risk of pregnancy loss, birth abnormalities, or other issues if a woman uses this medication throughout her pregnancy. However, consult your physician before taking this medication to be on the safe side.

The FDA has classified cefoperazone as a pregnancy category B drug. There was no indication of prenatal damage in animal investigations. In human pregnancy, there is no controlled data. Cefoperazone should only be used during pregnancy if there is a demonstrated necessity for it.

5. What is the difference between Cefoperazone and ceftriaxone?

Cefoperazone (Cefobid)

Cefobid is a prescription antibiotic used to treat the signs and symptoms of bacterial infections. It can be used alone or in combination with other medicines.

Cefobid is a member of the third-generation cephalosporins family of antibiotics.

Cefobid's safety and effectiveness in infants are unknown.

Ceftriaxone (Rocephin)

Ceftriaxone is a bacterial antibiotic used to treat a wide range of illnesses. It functions by inhibiting bacterial growth, and it also belongs to the class of cephalosporin antibiotics.

The half-life of ceftriaxone is prolonged. In neonates, it is not advisable to take this medication.

6. What is the mechanism of action of Cefoperazone?

Cefoperazone is like all beta-lactam antibiotics. It also binds to particular penicillin-binding proteins (PBPs) inside the bacterial cell wall, inhibiting the bacterial cell wall in the third and final stages of production. Autolysins, which are bacterial cell wall autolytic enzymes, are then used to lyse the cells.

7. Is Cefoperazone an antibiotic?

Cefoperazone is a novel beta-lactam antibiotic with significant antibacterial activity against both gram-positive and gram-negative bacteria.

A cephalosporin antibiotic is Cefoperazone. It's a drug used to treat bacterial infections. It is ineffective against colds, flu, and other viral illnesses.

Due to its broad antibacterial range, Cefoperazone is used to manage lower respiratory tract infections, gastrointestinal tract infections, skin infections, septicemia, and surgical prophylaxis.

8. Is Cefoperazone an antipseudomonal?

Yes, Cefoperazone is an antipseudomonal. Pseudomonas infections respond well to cefoperazone.

Antipseudomonal penicillins are antimicrobials that treat pseudomonal infections.

Cefoperazone is at least four times more effective than cefotaxime or moxalactam against Pseudomonas aeruginosa, and it's about as effective as azlocillin or piperacillin.

9. Why is sulbactam added to Cefoperazone?

Cefoperazone works as a bactericide by reducing bacterial cell wall production, while sulbactam works as a beta-lactamase inhibitor to boost Cefoperazone's antibacterial effectiveness against beta-lactamase-producing bacteria.

Sulbactam should improve Cefoperazone's antibacterial range and clinical efficacy against nosocomial and other infections such as plasmid-containing intestinal bacteria, Bacteroides species, and Acinetobacter species.

10. Is Cefoperazone safe in CKD patients?

Chronic kidney disease (CKD) is a disorder in which kidney function gradually deteriorates over time. Chronic renal disease is another name for CKD.

CKD is defined as ‘a reduction in glomerular filtration rate (GFR) of less than 60mL/minute/1.73m2 for more than three months’, regardless of the cause, and split into five phases depending on GFR.

Cefoperazone appears to be a promising broad-spectrum antibiotic for people with varying degrees of renal impairment.

During hemodialysis, the half-life of cefoperazone reduces significantly. Following a dialysis phase, dosing should be planned.

If you have any side effects that concern you or do not go away, please contact your physician immediately. Reach us! Get a medical opinion on the uses, dosages, side effects and precautions of Cefoperazone by consulting our specialists at Yashoda Hospitals.

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Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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