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Osteogenesis Imperfecta (OI)

Types, Causes, Symptoms, Complications, Prevention and Treatment

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What is Osteogenesis Imperfecta?

Osteogenesis imperfecta refers to a group of genetic disorders that affects the bones, make them weak, and lead to easy fracture. It is caused due to the presence of defective genes in the individual that affect how the body produces collagen.

This condition may be mild, wherein there are only a few fractures during an individual’s life, or it may be severe, wherein multiple fractures may occur without any apparent cause.

What are the types of Osteogenesis Imperfecta?

There are 4 major types of osteogenesis imperfecta:

Type I osteogenesis imperfecta: It makes an individual’s bones fragile, but there aren’t any bone deformities.

Type II osteogenesis imperfecta: Babies born usually have many fractures, and have breathing problems.

Type III osteogenesis imperfecta: These babies are shorter compared to their peers and may have many bone deformities, breathing problems, brittle teeth, a curved spine as well as rib cage deformities.

Type IV osteogenesis imperfecta: These babies have mild to serious bone deformities, a short stature, frequent fractures that may lessen after puberty as well, and a curved spine.

Osteogenesis imperfecta: What is Osteogenesis imperfecta, its Types and Causes?

What are the causes of Osteogenesis Imperfecta?

This condition is caused due to genetics. A positive family history indicates why an individual is suddenly from osteogenesis imperfecta.

References: 
  • Osteogenesis imperfect. Kids Health. Available at: https://kidshealth.org/en/parents/osteogenesis-imperfecta.html Accessed on June 29, 2020.
  • 2.Osteogenesis imperfecta. Healthline. Available at: https://www.healthline.com/health/osteogenesis-imperfecta Accessed on June 29, 2020.
  • 3.Osteogenesis imperfecta. Cleveland clinic. Available at: https://my.clevelandclinic.org/health/diseases/15807-osteogenesis-imperfecta Accessed on June 29, 2020.
  • 4. Osteogenesis imperfecta. Hopkins Medicince. Available at: https://www.hopkinsmedicine.org/health/conditions-and-diseases/osteogenesis-imperfecta Accessed on June 29, 2020.
Disclaimer:
“The content of this publication has been developed by a third party content provider who is clinicians and/or medical writers and/or experts. The information contained herein is for educational purpose only and we request you to please consult a Registered Medical Practitioner or Doctor before deciding the appropriate diagnosis and treatment plan.”

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