Beyond The Menstrual Pad Count: The Truth Of Abnormal Uterine Bleeding

Women’s menstrual cycles often reflect the pace and pressures of daily life. Long hours, stress, irregular sleep, and missed meals can disrupt hormonal balance, making periods arrive early or late, feel heavier, or last longer than usual. While this can be frustrating, it highlights how closely menstrual health is linked to overall physical and emotional well-being. A normal menstrual cycle typically occurs every 21–35 days in adults (21–45 days in adolescents), lasts 3–7 days, and involves moderate bleeding that does not interfere significantly with daily activities. Understanding what is normal helps women recognise when something feels off.
Abnormal uterine bleeding (AUB) refers to any change in the timing, duration, regularity, or amount of menstrual bleeding, including heavy periods, irregular cycles, bleeding between periods, or post-menopausal bleeding. It is not a disease but a sign of possible underlying issues such as hormonal imbalances, fibroids, infections, medication effects, or more serious conditions. Unfortunately, AUB is often under-reported, as many women are taught to normalise heavy or painful periods. Improving awareness and breaking menstrual stigma are essential to ensure early medical evaluation, prevent complications like anaemia, and protect long-term health.
From Taboo To Talked About: Realising How Common Abnormal Uterine Bleeding Is
Research has shown that 30% of women in their reproductive age experience abnormal uterine bleeding, thus making it an extensively clinically glaring worry.
| Category | Key Statistics | Clinical importance for patients |
| Overall prevalence | Affects up to 30% of reproductive-age women | Confirms that abnormal uterine bleeding is widespread and not unusual |
| Lifetime risk | Nearly 1 in 3 women experience abnormal uterine bleeding | Makes it normal for patients to seek a doctor’s help |
| Gynecological visits | One of the top 3 reasons for gynaecological visits | High healthcare burden |
| Adolescents | Greater than 70% Abnormal uterine bleeding in adolescents is due to ovulatory dysfunction | Usually benign, hormonal cause |
| Reproductive-age women | Most common causes are fibroids, polyps, and ovulatory dysfunction | Guides the likely diagnosis |
| Peri-menopausal women | Structural causes account for the majority of cases | Higher need for imaging/biopsy |
| Benign vs malignant | Greater than 90% cases of abnormal uterine bleeding are benign | Strong reassurance for patients |
| Endometrial cancer | Overall, present in less than 5% cases with abnormal uterine bleeding | Cancer is not common |
| Cancer risk by age | Risk rises after 45 years of age | Age-based screening importance |
| Obesity and Anovulation | Increases the risk of endometrial cancer by 2 to 4 times | Identifies higher-risk individuals |
| Heavy menstrual bleeding | Accounts for 50% of abnormal uterine bleeding cases | Most common bleeding complaint |
| Anemia | Seen in 305_60% women with chronic abnormal uterine bleeding | Explains fatigue and weakness |
| Impact on the quality of life effect | Comparable to chronic diseases | Justifies active treatment |
| LNG-IUS effectiveness | Reduces menstrual blood loss by 70-95% | Most effective medical option |
| Surgery avoidance | LNG-IUS minimises the need for hysterectomy in more than 60% of cases | Fertility-preserving benefit |
| Acute Abnormal Uterine Disorder | Represents less than 10% of abnormal uterine bleeding cases | Rare but dangerous |
| Hospitalization | Acute Abnormal uterine bleeding is a common cause for emergency admission of a patient. | Awareness of medical emergency cases |
Abnormal uterine bleeding (AUB) varies with age due to hormonal regulation and structural changes in the uterus, and is also influenced by factors such as pregnancy-related issues, infections, systemic diseases, alcohol use, and smoking. In adolescents, AUB is most commonly due to anovulatory cycles caused by an immature hypothalamic-pituitary-ovarian (HPO) axis after menarche, leading to hormonal imbalance and irregular, sometimes heavy bleeding that is usually benign. In reproductive-age women, AUB often results from benign hormonal and structural conditions such as fibroids, endometrial polyps, ovulatory dysfunction, and polycystic ovarian syndrome, which disrupt normal uterine function and menstrual regularity.
In perimenopausal women, declining ovarian function leads to irregular hormone production, frequent anovulation, and a higher incidence of conditions like fibroids, adenomyosis, and endometrial hyperplasia, making AUB more common and clinically significant. While AUB often raises concerns about cancer, most cases are non-cancerous, especially in younger women. However, the risk of endometrial cancer increases after 45 years, particularly in women with obesity, diabetes, chronic anovulation, or prolonged estrogen exposure, necessitating careful evaluation in older women.
Causes Of Abnormal Uterine Bleeding
Abnormal uterine bleeding is not a disease by itself but a symptom that can occur due to many reasons, such as hormonal problems, uterine conditions, blood disorders, or side effects of medicines. Historically, terms like menorrhagia, metrorrhagia, and dysfunctional uterine bleeding were used inconsistently to describe abnormal uterine bleeding, confusing diagnosis and management. This lack of clear terminology sometimes led to delayed diagnosis and improper treatment. To avoid this, a proper classification system became necessary, allowing doctors to focus on identifying the actual cause of the bleeding rather than merely describing its severity or irregularity.
To bring clarity, the International Federation of Gynaecology and Obstetrics (FIGO) introduced the PALM-COEIN classification system. It categorizes the causes of abnormal uterine bleeding into structural causes (PALM), which involve physical problems in the uterus that can be visualized on scans or confirmed by tests, and non-structural causes (COEIN), which are related to hormonal imbalances, medical conditions, or medications. This system helps doctors diagnose the problem accurately, choose the right tests and treatments, and provide better, more focused care to patients.
Structural Causes Of Abnormal Uterine Bleeding (PALM)
| Category | Condition | Description | Common clinical features |
|
P |
Polyps- Endometrial/cervical | Localised benign overgrowths of endometrial and cervical glands that project into the uterine cavity, disturbing natural endometrial shedding | Inter-menstrual bleeding, post-coital bleeding, heavy menstrual bleeding |
|
A |
Adenomyosis | Invasion of endometrial glands and stroma into myometrium, causing uterine enlargement, increased vascularity, and impaired uterine contraction | Heavy menstrual bleeding, dysmenorrhea, chronic pelvic pain |
|
L |
Leiomyoma (Fibroids) | Benign smooth muscle tumours of the uterus, submucosal and intramural fibroids, distort the uterine cavity and impair hemostasis by increasing endometrial surface area | Heavy or prolonged menstrual bleeding, pressure symptoms |
|
M |
Malignancy and pre-malignancy | Endometrial hyperplasia or carcinoma resulting from prolonged unstopped estrogen exposure with fragile and disorganized endometrial vasculature | Irregular bleeding, post menopausal bleeding, and bleeding in women greater than 40 years of age. |
Non-structural causes of Abnormal Uterine Bleeding (COEIN)
| Category | Condition | Description/ pathophysiology | Common clinical features |
|
C |
Coagulopathies | Caused by systemic disorders of coagulation, such as von Willebrand disease, leading to defective clot formation and increased blood loss | Heavy menstrual bleeding since menarche, easy bruising |
|
O |
Ovulatory dysfunction | Disturbances in the hypothalamic-pituitary and ovarian axis, causing irregular or absent ovulation, and prolonged exposure to estrogen without the opposition from progesterone | Irregular cycles, unpredictable bleeding |
|
E |
Endometrial dysfunction | Abnormal local endometrial hemostatic mechanisms, despite normal ovulation and uterine anatomy, resulting in ineffective vasoconstriction and repair | Heavy but regular menstrual bleeding |
|
I |
Iatrogenic causes | Bleeding caused by medicines or medical devices, namely, hormonal contraceptives, anticoagulants, or intrauterine devices | Breakthrough bleeding, prolonged bleeding |
|
N |
Not yet classified | Rare and poorly understood causes of abnormal uterine bleeding that do not fit the existing categories and are under research | Variable and unexplained patterns of bleeding |
Right Diagnosis For Abnormal Uterine Bleeding
Abnormal uterine bleeding is identified through a systematic evaluation involving patient history, clinical examination, laboratory tests, and imaging or tissue sampling as needed, with causes classified using the PALM-COEIN system.
To diagnose abnormal uterine bleeding, the doctor first takes a detailed medical history, including how often bleeding occurs, how long it lasts, how heavy it is, and associated symptoms. A normal menstrual period usually lasts between 2 and 7 days. Symptoms such as painful periods, fatigue, weight changes, hot flashes, or excess hair growth may suggest hormonal problems like PCOS. Information about current medications, existing illnesses, family history of bleeding disorders or cancer, and reproductive history is also reviewed.
A physical and pelvic examination is then performed to look for signs of anaemia, thyroid issues, infections, or structural problems. A speculum examination of the cervix is done to look for polyps, infections, or abnormal lesions, and tests like a Pap smear or screening for sexually transmitted infections may be performed. A bimanual examination helps assess the size, shape, and tenderness of the uterus and ovaries to detect any masses or abnormalities.
Laboratory tests such as pregnancy testing, blood counts, iron levels, hormone tests, and clotting studies help identify hormonal or systemic causes.
If necessary, imaging tests such as a transvaginal ultrasound are used to detect fibroids or polyps. Further tests, such as sonohysterography, endometrial biopsy, hysteroscopy, or MRI, may be done in selected cases.
This structured approach allows gynaecologists to accurately identify the cause of abnormal uterine bleeding and plan the most appropriate treatment.
Specific Treatment Plan For Abnormal Uterine Bleeding
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Gaining Control Over Unpredictable Flows Of Abnormal Uterine Bleeding
Management of abnormal uterine bleeding focuses on both immediate control and long-term treatment. The approach depends on the cause (PALM-COEIN classification), the patient’s age, severity of bleeding, associated medical conditions, and future pregnancy plans. Treatment options include medical therapy, procedures, surgery, and emergency care when needed.
Medical Management or first-line therapy is typically the initial approach for managing long-term abnormal uterine bleeding episodes and can be divided into hormonal and non-hormonal therapies.
Non-hormonal therapies are favoured by patients who do not want hormonal side effects or who desire to maintain their fertility, as they are only used during menstruation. Tranexamic acid (antifibrinolytic) works by preventing the breakdown of fibrin, the protein responsible for the formation of blood clots, and decreases menstrual blood loss by 30-50%. Tranexamic acid does not interfere with ovulation or hormonal levels. Non-steroidal anti-inflammatory drugs are used to reduce prostaglandin levels. Prostaglandin is associated with pain and bleeding. NSAIDs are thus effective in reducing blood flow by 25%-50% along with menstrual pain.
Hormonal treatments for abnormal uterine bleeding stabilise the uterine lining, ensuring a more predictable and lighter shedding pattern. Levonorgestrel-releasing intrauterine system (LNG-IUS) is a long-acting, reversible contraceptive device placed inside the uterus that continuously releases a low dose of progestin. This therapy is known to be the gold standard in treating abnormal uterine bleeding with highly effective long-term management for up to 3-8 years. It is known to reduce blood loss by over 90%. Advantages include long-term efficacy, high satisfaction, effective contraception and minimal side effects. This therapy is combined with combined hormonal contraceptives, progestin-only pills, injections or implants, and gonadotropin-releasing hormone agonists or antagonists.
Surgical treatment of abnormal uterine bleeding is considered when medical management fails or is contraindicated. Dilation and curettage, Hysteroscopy with targeted resection, endometrial ablation, uterine artery embolisation, and hysterectomy are normally the techniques used.
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Beyond the Bleed: Final Perspectives on Abnormal Uterine Bleeding
Abnormal uterine bleeding (AUB) is a common gynaecological condition that reflects disturbances in normal menstrual patterns. It can be caused by an imbalance in hormones, structural abnormalities in the uterus, systemic diseases, or malignancy. Correct diagnosis requires careful clinical evaluation. Early identification and tailored management are important to improve the quality of life and prevent future reproductive problems like anaemia and infertility.
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