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Yashoda Hospitals > Imibuzo Evame Ukubuzwa Ngezokwelapha > I-Sulfamethoxazole

I-Sulfamethoxazole: Imibuzo Evame Ukubuzwa Iyaphendulwa

Iyini i-Sulfamethoxazole?

Kungumuthi wama-antibiotic ovela eqenjini lama-sulfonamides noma izidakamizwa ze-sulfa. Ngokuvamile, unikezwa ngomlomo. Lo muthi unendlela yokusebenza yama-bacteriostatic ngokumelene nama-bacteria aqondiwe, okusho ukuthi uvimbela isenzo sama-bacteria ngokunciphisa ukukhula kwama-bacteria. I-Folic acid idlala indima ebalulekile ekwakhiweni kwama-nucleic acid namaprotheni adingekayo ekuhlukaniseni ama-bacteria. Iphazamisa ukwakheka kwe-folic acid kuma-bacteria aqondiwe, ngaleyo ndlela iyeke ukukhiqizwa kwe-folic acid futhi ekugcineni ivimbele ukwanda kwama-bacteria.

Yiziphi izindlela zokusebenzisa le antibiotic?

Le mithi yokulwa namagciwane ivame ukunikezwa kanye ne-trimethoprim ukuze ibe nesenzo esithuthukisiwe sokusebenzisana ngokumelene nokukhula kwamagciwane. Odokotela bavame ukuyinika imithi yokuqeda ukutheleleka kwamagciwane emgudwini womchamo, i-otitis media (ukutheleleka kwendlebe ephakathi) ezinganeni, iziqephu ezibukhali ze-bronchitis engapheli, uhudo lwe-bacillary (I-Shigella-okubangelwa yi-enteritis), uhudo lwabahambi (okubangelwa yi- E. coli) kanye nokuvimbela noma ukwelashwa kwe-Pneumocystis carinii pneumonia (i-pneumonia enzima kakhulu). Lo muthi awufanele izingane ezingaphansi kweminyaka emi-2 ubudala.

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    Yimiphi imiphumela emibi ehambisana nayo?

    Imiphumela ethile emibi iyenzeka ngokuphathwa kwe-Sulfamethoxazole. Akudingeki ukuthi yonke imiphumela emibi eshiwo ngenhla yenzeke. Uma le miphumela iqhubeka isikhathi eside noma iba mibi kakhulu, thola usizo lodokotela ngokushesha. Imiphumela emibi evamile uhudo, ukuhlanza, isicanucanu, kanye nokulahlekelwa isifiso sokudla. Izimo ezingathi sína ezihlobene nazo ubuthakathaka, igazi emchameni, ukozela okungazelelwe nokukhulu, ukujuluka okungavamile kanye nokungaboni kahle. Izimo ezidinga usizo lodokotela ngokushesha ukushaya kwenhliziyo okungajwayelekile, ukuqina kwentamo, ukuxhuzula, kanye nekhanda elibuhlungu eliqhubekayo.

    Kuyini i-Sulfamethoxazole

    Ukusetshenziswa kwe-Sulfamethoxazole

    Imiphumela emibi ye-Sulfamethoxazole

    Okubhekwayo

    1. I-NCBI: https://pubchem.ncbi.nlm.nih.gov/compound/Sulfamethoxazole
    2. go.drugbank: https://go.drugbank.com/drugs/DB01015
    3. I-MayoClinic: https://www.mayoclinic.org/drugs-supplements/sulfamethoxazole-and-trimethoprim-oral-route/description/drg-20071899
    4. I-WebMd: https://www.webmd.com/drugs/2/drug-3409-1071/sulfamethoxazole-trimethoprim-oral/sulfamethoxazole-trimethoprim-suspension-oral/details
    5. Ulwazi Lwezokwelapha i-HIV.gov: https://clinicalinfo.hiv.gov/en/drugs/sulfamethoxazole-trimethoprim/tablet-tablet-double-strength
    6. Izidakamizwa: https://www.drugs.com/drug-interactions/clindamycin-with-septra-690-0-2128-1385.html
    7. UmamaKubaby: https://mothertobaby.org/fact-sheets/sulfamethoxazoletrimethoprim-bactrim-septra-pregnancy/
    8. I-NCBI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426978/
    9. Izidakamizwa: https://www.drugs.com/medical-answers/can-a-glass-or-two-be-taken-with-306327/

    Disclaimer: Ulwazi oluhlinzekwe lapha lunembile, lubuyekeziwe futhi luphelele ngokwemikhuba emihle yeNkampani. Sicela uqaphele ukuthi lolu lwazi akufanele luphathwe njengokungena esikhundleni sokubonisana noma iseluleko sezokwelapha ngokomzimba. Asiqinisekisi ukunemba nokuphelela kolwazi oluhlinzekwe kanjalo. Ukungabikho kwanoma yiluphi ulwazi kanye/noma isixwayiso kunoma yimuphi umuthi ngeke kucatshangelwe futhi kuthathwe njengesiqinisekiso esicashile seNkampani. Asithathi noma yimuphi umthwalo wemfanelo ngemiphumela evela kulwazi olushiwo ngenhla futhi sikuncoma kakhulu ukuthi ubonisane ngokomzimba uma kukhona imibuzo noma ukungabaza.

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    Imibuzo Evame Ukubuzwa Nge-Sulfamethoxazole

    Umuthi ngamunye ufinyelela izinga lawo eliphezulu phakathi nehora elilodwa kuya kwamane ngemva kokuwusebenzisa ngomlomo. Kodwa-ke, isigamu sokuphila kwe-sulfamethoxazole singamahora ayi-10 kanti i-trimethoprim ingamahora ayi-8 kuya kwayi-10 egazini, iminonjana yesidakamizwa ingatholakala emchameni kuze kube amahora angama-72 ngemva kokusetshenziswa ngomlomo okukodwa.

    Nakuba kungekho mibiko yokuxhumana kwemithi phakathi kwala ma-antibiotic amabili ngesikhathi esetshenziswa ngasikhathi sinye, akusho ukuthi akukho ukusebenzisana okunjalo okukhona. Ngakho-ke, umuntu kufanele axhumane nochwepheshe wezempilo ngaphambi kokusebenzisa inhlanganisela enjalo yama-antibiotic.

    I-Phenazopyridine iyisidakamizwa sendawo sokuqeda izinhlungu, esiphinde siboniswe ezifweni zomchamo. Akukho mibiko yokuxhumana kwemithi phakathi kwale mithi emibili ekusetshenzisweni kwayo ngasikhathi sinye. Akusho ukuthi akukho ukusebenzisana okunjalo okukhona. Ngakho-ke, umuntu kufanele axhumane nomhlinzeki wezempilo ngaphambi kokusebenzisa inhlanganisela enjalo yemithi.

    Cha, akuyona i-steroid. Ingaphansi kwesigaba sama-antibiotic (i-folic acid inhibitors) futhi iyinhlanganisela ye-isoxazole. Ngaphezu kwalokho, iyi-antibiotic ye-sulfonamide enezimpawu ze-bacteriostatic.

    Yebo. Ingomunye wemithi ephumelela kakhulu yokwelapha izifo zamagciwane zomgudu womchamo. Ingaphathwa ngomlomo. Ngaphezu kwalokho, iqala ukusebenza kwayo ngokumelene namagciwane ahlala emgodini womchamo zingakapheli amahora angu-1 kuya kwangu-4 kusukela ekusetshenzisweni. Ngenxa yokuthi i-sulfamethoxazole iyi-antibiotic ebanzi, ingasebenza ngokumelene namagciwane ahlukahlukene abangela izifo zomgudu womchamo.

    Njalo thintana nomhlinzeki wezempilo ngaphambi kokuthatha imithi enjalo ngenkathi uncelisa ingane yakho. Akudingeki ukuyeka ukuncelisa ngenkathi uthatha lo muthi. Kodwa-ke, ungadlulela ebisini lebele ngamachashazi amancane, kodwa akuyona indaba ekhathazayo kakhulu ngaphandle kokuthi ingane izalwe ngaphambi kwamasonto angu-37 okukhulelwa noma uma ingane ihlushwa yizimo ezithile njengokuntuleka kwe-G6PD.

    Womabili lawa ma-antibiotic angamalungu amaqembu ahlukene ama-antibiotic. Kodwa umsebenzi walokhu kuhlanganiswa uphakeme kakhulu kunomphumela wawo ngamunye. Lokhu kungenxa yesenzo sawo esithuthukisiwe sokusebenzisana ekwakhiweni kwe-folic acid yamabhaktheriya. Ngakho-ke, kukhona ukuvinjelwa kokwanda nokukhula kwamabhaktheriya ngezinga elikhulu.

    Yebo, iyi-antibiotic enamandla. Iwumuthi obanzi osebenza kahle ngokumelene namagciwane ahlukahlukene. Ngokuvamile ukhonjiswa ukuqeda ukutheleleka kwamagciwane emgudwini womchamo, ukutheleleka kwendlebe ephakathi, i-bronchitis, isifo sohudo se-bacillary, isifo sohudo esihambayo, kanye nokuvimbela noma ukwelashwa kwe-pneumonia.

    Kungase kukulethele isifo sohudo, ukuhlanza, isicanucanu kanye nokulahlekelwa yisifiso sokudla. Izimo ezingavamile nezingathi sína ezihlobene nazo ubuthakathaka, igazi emchameni, ukozela okungazelelwe kanye nokweqile, ukujuluka okungavamile kanye nokungaboni kahle. Izimo ezidinga ukunakekelwa kwezokwelapha okusheshayo ukushaya kwenhliziyo okungajwayelekile, ukuqina kwentamo, ukuxhuzula, kanye nekhanda elibuhlungu elingapheli.

    Kufanele kugwenywe ngesikhathi sokukhulelwa, ikakhulukazi ngesikhathi se-trimester yokuqala. Lokhu kungenxa yokuthi kungadala umphumela we-antifolate, okubangela ezinye izinkinga zokuzalwa ezifana nokukhubazeka kwe-neural tube.

    Cha. Ukuphuza utshwala ngaleli antibiotic akukhuthazwa nhlobo. Lokhu kungenxa yokuthi kungabangela imiphumela ethile emibi njengesicanucanu, ukuhlanza, umuzwa wokuqaqamba, ukushaya kwenhliziyo okusheshayo, umuzwa ongathandeki wokufudumala kanye nokubomvu kwesikhumba. Ngesikhathi uphuza, umuntu kufanele agweme imithi ethile yomkhuhlane evamile kanye nemithi yokuhlanza umlomo, njengoba ingase ibe notshwala.
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