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Yashoda Hospitals > Diagnostics > Ukuhlolwa kwe-HCV Antibody

Iyini ukuhlolwa kwe-antibody ye-HCV?

Ukuhlolwa kwe-antibody ye-HCV kusetshenziselwa ukuxilonga ukutheleleka kwegciwane le-hepatitis C. Ukuhlolwa kwegazi okuhlonza ama-antibodies e-hepatitis C egazini. Lapho umzimba utheleleka ngegciwane le-hepatitis C, umzimba uzokhiqiza ama-antibodies okulwa nokutheleleka kwegciwane. Ukuhlolwa kwe-HCV kuhlonza la ma-antibodies egazini. Lokhu kuhlolwa kunconywa emaqenjini asengozini enkulu, okuhlanganisa abasebenzisi bezidakamizwa, abasebenzi bezempilo, kanye nezingane zomama abane-HCV. Lokhu kuhlolwa kunconywa futhi uma unezimpawu ezifana nokucanuzela kwenhliziyo, ukukhathala, umchamo omnyama, uhudo, i-jaundice, kanye nokuncipha kwesifiso sokudla njengoba i-HCV ithelela isibindi.

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Ukuhlolwa kwe-antibody ye-HCV kusetshenziselwa ukuhlonza ukuchayeka kwangaphambilini noma ukutheleleka kwamanje ngegciwane le-hepatitis C. Lokhu kuhlolwa kuhlonza amasosha omzimba egciwane le-hepatitis C, ngakho-ke akunakusiza ekuhlukaniseni phakathi kokutheleleka okusebenzayo kwegciwane kanye nokutheleleka kwangaphambilini. Ngezinye izikhathi, umphumela ongalungile unikezwa ekuhlolweni okubuthakathaka okuhle.

Imiphumela yokuhlolwa ebonisa ama-antibodies e-HCV angasasebenzi ikhombisa ukuthi awekho ama-antibodies e-HCV egazini. Laba ziguli abanazo izifo ze-HCV zamanje noma zangaphambilini. Ukuhlolwa kwe-antibody ye-HCV okusabela kubonisa ukutheleleka okucatshangelwayo kwe-HCV. Ukuhlolwa kwe-HCV RNA kungaphakanyiswa ngemuva kokuhlolwa kwe-antibody ye-HCV ukuze kutholakale ukuthi isiguli esinjalo sike saba nesifo muva nje.

Kuphakanyiswa ukuthi wonke umuntu oseqenjini leminyaka eli-18 kuya kwengama-79 kufanele ahlolwe ngokuhlolwa kwe-antibody ye-HCV. Abanye abantu abaguli ngenxa yokutheleleka ngegciwane le-hepatitis C, kodwa kuyalimaza isibindi sabo kancane kancane. Ukwenza ukuhlolwa kungavimbela nokusabalala kwaleli gciwane. Uma ungoweqembu eliyingozi njengesisebenzi sezempilo noma umsebenzisi wezidakamizwa ongekho emthethweni, kufanele wenze lokhu kuhlolwa.

Ukuhlolwa kwe-antibody ye-HCV ukuhlolwa kwegazi okusetshenziselwa ukuhlola ukutheleleka kwe-hepatitis C. Ukuhlolwa kuthola ama-antibodies e-HCV egazini ngosizo lwe-Enzyme Immunoassay. Imiphumela yokuhlolwa ibonakala njengemihle neyimbi, okubonisa ukutheleleka kwegciwane le-hepatitis C okwedlule noma kwamanje emzimbeni.

I-antibody ye-HCV enhle isho ukuthi umuntu utheleleke ngegciwane le-hepatitis C. Lokhu kutheleleka kungaba nganoma yisiphi isikhathi empilweni yakhe. Ukutheleleka kwe-HCV kubangela ukwakheka kwama-antibodies ngokumelene negciwane le-hepatitis C emzimbeni. Lawa ma-antibodies azohlala egazini futhi abonakala ngalolu vivinyo.

Uhla olujwayelekile lwe-HCV "alutholakali" njengoba lubonisa ukuthi awukaze utheleleke ngaleli gciwane. Uhla oluningi lokuhlolwa kwe-antibody ye-HCV luyi-10–100,000,000 IU/mL (1.0 - 8.0 log IU/mL). Ucwaningo lukhombisile ukuthi ukuhlolwa kunganikeza imiphumela engalungile cishe ku-10% wamasampula.

Ama-antibodies e-HCV akhiwa njengendlela yokulwa negciwane le-hepatitis C emzimbeni. Lawa ma-antibodies ahlala emzimbeni impilo yonke futhi awanyamalali. Kodwa-ke, ngaphansi kweziguli eziyi-15%, la ma-antibodies ayanyamalala ngokuzenzekelayo. Ukususwa kwala ma-antibodies akubonisi ukusekelwa kokutheleleka emzimbeni.

Ama-antibodies e-HCV akhiqizwa ukuphendula ukutheleleka futhi ahlala egazini kuze kube phakade. Kodwa-ke, la ma-antibodies e-HCV kubantu awavikeli umzimba ekuthelelekeni ngegciwane le-hepatitis C. Indlela yokuvikela umzimba kuleli gciwane iqondiswa amaseli e-CD4 kanye ne-CD8 T. Lawa maseli asiza ekuhlinzekeni ngokuzivikela okuzivumelanisa nezimo kumuntu ngamunye.

Ama-antibodies e-HCV akhiwa njengendlela yokulwa nokutheleleka kwe-HCV. Lawa ma-antibodies angahlala egazini iminyaka engama-20. Lawa ma-antibodies ahlala emazingeni atholakalayo ngisho nangemva kokuncipha kwezimpawu zomtholampilo. Kanye nalawa ma-antibodies, i-antigen kanye negciwane nakho kuhlala emzimbeni emazingeni aphansi uma kuqhathaniswa.

Uma umphumela wokuhlolwa ungewona owamasosha omzimba i-HCV, ama-antibodies e-HCV awatholakali egazini futhi umuntu akanayo i-HCV. Uma umphumela wokuhlolwa ungowamasosha omzimba i-HCV, kubonisa ukutheleleka kwe-HCV okucatshangelwayo. Kulezi zimo, kwenziwa ukuhlolwa kwe-HCV RNA ukuze kutholakale izinkinga ezisebenzayo nezamanje zokutheleleka kwe-HCV.

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