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Yashoda Hospitals > Diagnostics > Coombs Test

Kuyini ukuhlolwa kwe-Coombs?

Ukuhlolwa kwe-Coombs ukuhlolwa kwe-antiglobulin noma ukuhlolwa kwe-RBC antibody okubheka ama-antibodies aqondise amaseli abomvu egazi egazini lakho. Ama-antibodies ayingxenye yesimiso somzimba sokuzivikela. Alwa nezifo kodwa ngezinye izikhathi ahlasela ngephutha amaseli akho aphilile.

Kukhona amanye ama-antibodies ahlobene nohlobo lwegazi lakho. Amaseli egazi abomvu omuntu ngamunye ahlukile. Uma isimiso sakho somzimba sokuzivikela sithola ama-antibodies angahambisani nesakho, sizowakhiqiza.

Kunezinhlobo ezimbili zokuhlolwa kwe-Coombs. Ukuhlolwa okuqondile kwama-antibodies kuma-RBC. Ukuhlolwa okungaqondile kwama-antibodies ku-serum yegazi lakho.

 

Isetshenziselwa ini i-Coombs Test?

Ukusetshenziswa kokuhlolwa kwe-Coombs kuhlanganisa ukufuna ama-antibodies ezindaweni zamaseli abomvu egazi. Lawa ma-antibodies abonisa i-hemolytic anemia, isimo lapho igazi lakho lintula khona amaseli abomvu egazi ngenxa yokubhujiswa kwawo kusenesikhathi. Iseli elibomvu legazi elijwayelekile liphila cishe izinsuku ezingu-120; noma kunjalo, libhubhisa amaseli abomvu egazi kakhulu ngaphambi kophawu lwezinsuku ezingu-120 ezigulini ezine-hemolytic anemia. 

Ukuqonda imiphumela yokuhlolwa kwe-Coombs Test

Ukuhlolwa kwe-Coombs kukhomba ukuhlangana kwamaseli abomvu egazi. Kubonisa ukuthi akutholanga ma-antibodies noma ukuthi inani lama-antibodies atholakele cishe lalilincane. Uma kungekho clump etholakele, ukuhlolwa kuba negative.

Imiphumela emihle nemibi ekuhlolweni kwe-DAT kanye ne-IAT inezincazelo ezahlukene. Ukuhlanganiswa kwamaseli abomvu egazi kunikeza imiphumela emihle ngesikhathi sokuhlolwa.

 

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imibuzo ejwayelekile ukubuzwa

Ukuhlolwa kwe-Coombs kunquma ukuthi igazi liqukethe izinhlobo ezithile zama-antibodies. Uma isimiso somzimba sokuzivikela sithola okuthile ngendlela engafanele, ngezinye izikhathi singase sikhiqize ama-antibodies ngokumelene namaseli. Ukuhlolwa kwe-Coombs kusetshenziselwa ukubona ukuthi unama-antibodies egazini lakho abangela ukuthi isimiso somzimba wakho sokuzivikela sihlasele futhi sibulale amaseli akho abomvu egazi. Uma lokhu kwenzeka, ungase ube ne-hemolytic anemia.

Yenza ukuhlolwa kwe-Coombs okuqondile kusampula yamaseli abomvu egazi. Kuhlonza ama-antibodies akhona ekujikelezeni kwegazi angase anamathele kumaseli abomvu athile egazi, okudala izinkinga ekuxubeni kwegazi. Kungathola ama-antibodies asevele eboshelwe kumaseli abomvu egazi.

 

Ukuhlolwa kwe-Coombs kungokwezinhlobo ezimbili - okuqondile nokungaqondile. Ukuhlolwa kwe-Coombs, noma ukuhlolwa kwe-antiglobulin okuqondile, kuyindlela esetshenziswa kakhulu ekuxilongeni i-hemolytic anemia. Ukuhlolwa kwe-Coombs okungaqondile kusetshenziswa kuphela ekuhlolweni kwabesifazane abakhulelwe ngaphambi kokubeletha kanye nokumpontshelwa igazi. Igazi liqoqwa emthanjeni wengalo bese ligezwa ukuze kuqoqwe amaseli egazi abomvu ukuze kuhlolwe i-Coombs okuqondile.

Ekuhlolweni kwakho kokuqala ngaphambi kokubeletha, ukuhlolwa kwegazi lakho kwenziwa ukuze kubonakale ukuthi wake wazizwa yini ukuthi une-Rh-positive blood. Ngesikhathi sokukhulelwa kwasekuqaleni, bonke abesifazane bahlolwa ngokungaqondile i-Coombs. Uma une-Rh-negative futhi imiphumela yakho yokuhlolwa ikhombisa ukuthi awunazo izimpawu, yenza ukuhlolwa kwesibili phakathi kwamasonto angama-24 nama-28.

Uma umphumela wokuhlolwa kwe-Coombs ubonisa ukuthi une-anemia, izinkinga ezimbili ezinkulu ezinganeni yi-anemia kanye ne-jaundice. Into edidayo ukuthi yiphesenti elincane kakhulu lezingane ezisanda kuzalwa ezine-Coombs ezizothola lobu bunzima, kanti ezinye izingane ezingenayo i-Coombs zingase zibe nabo. Ngakho-ke, ukuhlolwa okuhle kubonisa ukuthi ukuqapha i-anemia kanye ne-jaundice kubaluleke kakhulu kunokunquma ukuthi yiziphi izingane ezidinga ukwelashwa.

  • Ukuhlolwa kwe-Direct Coombs

Ukuhlolwa kwe-Coombs okuqondile kubheka ama-antibodies kuma-RBC. Umzimba wakho ungase ukhiqize ama-antibodies ngenxa yesifo, noma kungenzeka ukuthi atholakale ngokumpontshelwa igazi.

  • Ukuhlolwa kwe-Coombs okungaqondile

Ukuhlolwa kwe-Coombs okungaqondile kuthola ama-antibodies engxenyeni yoketshezi egazini lakho. Ama-antibodies angahlasela amaseli abomvu egazi, kodwa awanamatheli kuwo.

Ngaphambi kokuvakashela ilabhorethri yezifo, udokotela wakho uzokuyala ukuba uphuze amanzi. Imithi ethile kungadingeka iyekwe ngaphambi kokuhlolwa, kodwa kuphela uma udokotela wakho ekuyala ukuba wenze kanjalo.

Ungase uzwe ukungakhululeki okuncane noma umuzwa wokuncinza ngesikhathi sokuhlolwa lapho ukhipha igazi. Kodwa-ke, lokhu kuvamile isikhathi esifushane futhi kuncane kakhulu.

Ngemva kokususwa kwenaliti, ungase ube nomuzwa wokubhoboza endaweni ejovwe. Kumelwe ufake ingcindezi endaweni lapho inaliti ijovwe khona.

 

Uma udokotela wakho eqinisekisa ukuthi une-RBC count ephansi, angase akunike ukuhlolwa kwe-Coombs ukuze kutholakale uhlobo lwe-anemia onayo. Okulandelayo yimiphumela embalwa engavamile:

  • Isizungu noma ukuquleka
  • I-Hematoma, isikhwama esigcwele igazi ngaphansi kwesikhumba
  • Ukutheleleka kugwenywa ngokuhlanza isikhumba kahle ngaphambi kokufaka inaliti
  • Ukopha okungalawuleki

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