Ukuhlolwa Kwamaprotheni Asabela Kahle Ka-C: Ukusetshenziswa Nezinkomba, Izinzuzo, Izinhlobo, Ukulungiselela, Inqubo nokuningi

Iyini iphrotheni e-C-reactive (CRP)?

Ukuhlolwa kwe-C-reactive protein (CRP) ukuhlolwa kwegazi okulula okukala izinga le -C-reactive protein emzimbeni. Le protein ikhiqizwa yisibindi bese ikhishwa egazini ngesikhathi sokuvuvukala, okuyimpendulo yomzimba ekuthelelekeni, ekulimaleni, noma ekucasukeni. Amazinga e-CRP angakhuphuka ngokushesha, ngezinye izikhathi kungakapheli amahora, lapho izicubu zithintekile. Nakuba ukuhlolwa kungasitholi isifo esithile, kusiza ukukhombisa ukuba khona kanye nobukhulu bokuvuvukala komzimba. Amazinga aphezulu e-CRP asikisela ukuvuvukala okusebenzayo, kuyilapho amazinga aphansi ngokuvamile ekhombisa ukuvuvukala okuncane noma okungekho nhlobo. Imiphumela ye-CRP, elinganiswa ngama-milligram ngelitha (mg/L), ihunyushwa kanye neminye imiphumela yezokwelapha ukuhlola isimo sokuvuvukala sesiguli sonke.

Ukusetshenziswa kanye nezinkomba zokuhlolwa kwephrotheni esabela ku-C

Ezokwelapha, ukusetshenziswa kanye nezinkomba zokuhlolwa kwephrotheni esabela ku-C kuhlobene kakhulu kodwa kunezincazelo ezihlukile ezimweni ezahlukene zezokwelapha.

Izinkomba ("Nini" kanye "Nokuthi Kungani") ziyizizathu noma izimpawu eziqondile ezisiza udokotela ukuthi ahlele ukuhlolwa. Zichaza isimo sesiguli ngesikhathi kuhlolwa.

Izimpawu zokutheleleka zifaka phakathi umkhuhlane ongachazeki, ukubanda, i-tachycardia, noma i-tachypnea.

Izimo zokuvuvukala okusolwayo zingase zivele nobuhlungu bamalunga, ukuvuvukala, noma ukukhathala okungachazeki.

Ukuqapha ngemva kokuhlinzwa kuhlanganisa ukuhlola izimpawu zokuqala zokutheleleka noma izinkinga ngemva kokuphothulwa kwenqubo.

Ukuhlolwa kwengozi kuhlanganisa ukuhlola isiguli ngesifo esithile senhliziyo, ikakhulukazi kusetshenziswa i-CRP (hs-CRP) ezwela kakhulu.

Ukusetshenziswa (“Kanjani” kanye “Nokwenzenjani”) kubhekisela ezinhlosweni noma emisebenzini ebanzi lapho kusetshenziswa khona ukuhlolwa kwephrotheni esabelayo ye-C ekuphathweni kokunakekelwa kwesiguli. Kuchaza lokho imiphumela yokuhlolwa kwephrotheni esabelayo ye-C esiza odokotela ukukufeza.

Ukutholwa: Ukuhlonza ukuvuvukala komzimba emzimbeni.

Ukusekelwa kokuxilonga: Ukusiza udokotela ukuhlukanisa phakathi kokutheleleka ngamagciwane kanye namagciwane (ukutheleleka ngamagciwane kuvame ukuhlotshaniswa namazinga aphezulu e-C-reactive protein).

Ukuhlola ukwelashwa: Ukuhlola ukuthi ukwelashwa (isb., ama-antibodies noma ama-anti-inflammatory agents) kuyasebenza yini ngokubheka ukuthi imiphumela yokuhlolwa kwe-C-reactive protein iyehla yini ngokuhamba kwesikhathi.

Ukulungiselela ukuhlolwa kwe-C-reactive protein:

Isiguli kufanele sigweme ukuvivinya umzimba okunzima, njengokuqeqeshwa kwesisindo okunamandla noma ukugijima ibanga elide, ngaphambi kokuhlolwa kwephrotheni esabela ku-C. Ukuvivinya umzimba okunamandla kungakhuphula amazinga ephrotheni esabela ku-C okwesikhashana.

Iziguli kufanele zazise ochwepheshe bezempilo ngayo yonke imithi kanye nezithako ezithathiwe, ikakhulukazi imithi yokulwa nokuvuvukala, ama-statin, ukwelashwa kokufaka esikhundleni sama-hormone, amaphilisi okulawula ukuzalwa, kanye nezithako ze-magnesium. Kufanele futhi bahlehlise ukuhlolwa uma benesifo sesikhashana, njengomkhuhlane noma umkhuhlane, noma ukulimala muva nje, njengoba lezi zimo zingakhuphula amazinga e-C-reactive protein futhi zithinte imiphumela.

Izidingo zokuzila ukudla kokuhlolwa kwephrotheni esabela ku-C:

Ukuhlolwa kwe-CRP okujwayelekile akudingi ukuzila ukudla, kanti ukuhlolwa kwe-high-sensitivity C-reactive protein (hs-CRP) kudinga ukuzila ukudla kwamahora angu-9-12 ngoba kwenziwa kanye nephaneli ye-fasting lipid.

Kunconywa ukuphuza amanzi amaningi ngaphambi kokuhlolwa kwe-C-reactive protein ukuze kube lula ukuqoqwa kwegazi nokugwema ukubhema, njengoba ukubhema kungathinta imiphumela.

Inqubo yokuhlolwa kwephrotheni esabela ku-C:

Kutholakala umthambo ofanele, ngokuvamile osendololwaneni yangaphakathi noma ngemuva kwesandla, bese indawo ihlanzwa ngesibulali-magciwane. Kuboshwa ibhande elinwebekayo engalweni engenhla ukuze umthambo ubonakale kakhudlwana, bese kufakwa inaliti ehlanzekile. Inani elincane legazi libe seliqoqwa ebhodleleni elihlanzekile noma epayipini lokuhlola. Uma isampula isitholiwe, inaliti iyasuswa, ingcindezi ifakwa ngekotini noma i-gauze ukulawula ukuphuma kwegazi, bese kufakwa ibhandishi elincane.

Ngemva kokuba imiphumela yokuhlolwa kwe-C-reactive protein ithunyelwe elabhorethri, iyahlaziywa ngokusebenzisa enye yezindlela ezilandelayo ezifana

• Ukuhlolwa kwe-Immunoturbidometry: Ukuhlolwa okuzenzakalelayo lapho ama-antibodies ebopha khona kuphrotheni e-C-reactive (CRP) kusampula, bese kulinganiswa ukuminyana okubangelwayo ukuze kutholakale ukuhlushwa kwe-CRP.
• Ukuhlanganiswa kwe-Latex: Indlela yokwenza ngesandla lapho izinhlayiya ze-latex ezimbozwe ngeprotheyini elwa ne-C-reactive zixutshwa khona ne-serum yesiguli. Uma kukhona iphrotheyini elwa ne-C-reactive, ukuhlangana (ukuhlanganiswa) kubonakala kungakapheli imizuzu emibili.
• I-Nephelometry kuyindlela elinganisa ukusabalala kokukhanya ukuze ilinganise amazinga aphansi eprotheyini e-C-reactive (CRP), evame ukusetshenziswa esivivinyweni seprotheyini e-C-reactive (hs-CRP) yokuzwela okuphezulu.

Imiphumela yokuhlolwa kwephrotheni esabela ku-C ivame ukutholakala zingakapheli amahora angu-48. Izinga elijwayelekile lephrotheni esabela ku-C libhekwa njengelijwayelekile uma lingaphansi kuka-10mg/L. Njengoba kuxoxiwe, amazinga aphezulu ephrotheni esabela ku-C abonisa ukuvuvukala, okungabangelwa ukutheleleka, ukulimala, noma isimo esingamahlalakhona njenge-rheumatoid arthritis.

Izinzuzo zokuhlolwa kwephrotheni esabela ku-C:

• Ukutholakala kusenesikhathi kwanoma yikuphi ukutheleleka.
• Ukuhlolwa kwengozi yesifo senhliziyo
• Ukuqapha izimo zezifo ezingamahlalakhona (zesikhathi eside)
• Ukulandelela ngemva kokuhlinzwa
• Ukuhlukanisa phakathi kwezifo ezimbili

Izici Ezithonya Imiphumela Yokuhlolwa Kwephrotheni Esebenzayo Ye-C:

Izinto eziningi zithonya imiphumela yephrotheni ye-C-reactive ngoba isibindi sikhipha le phrotheni ngenxa yokuvuvukala, kungaba okubukhali noma okungamahlalakhona. Izinto ezingathinta imiphumela yephrotheni ye-C-reactive (CRP) zifaka:
Izifo ezifana nezifo ezibangelwa amagciwane, amagciwane, noma isikhunta, kanye nokulimala kwamuva noma ukululama ngemva kokuhlinzwa.

• Izimo zokuvuvukala okungapheli, okuhlanganisa izifo zokuzivikela komzimba njenge-Rheumatoid Arthritis, i-Lupus, i-Inflammatory Bowel Disease, isifo sikashukela kanye ne-Hypertension.
• Izici zendlela yokuphila njengokukhuluphala ngokweqile, amafutha amaningi emzimbeni, ukubhema, kanye nesimiso sokuhlala phansi.
• Amaphethini omsebenzi womzimba, lapho ukuvivinya umzimba okunamandla ngaphambi nje kokuhlolwa kungathinta imiphumela okwesikhashana.
• Imikhuba yokudla, ikakhulukazi ukudla okunamafutha amaningi e-trans noma ushukela ocolisisiwe, kuyilapho ukudla okulwa nokuvuvukala njengezithelo, imifino, i-fiber, namafutha enhlanzi kungase kusekele ibhalansi enempilo yokuvuvukala.
• Ukucindezeleka okungapheli kanye nekhwalithi yokungalali kahle kuhlotshaniswa nokuvuvukala komzimba.

Izinhlobo zokuhlolwa kwephrotheni esabela ku-C:

Ukuhlolwa kwephrotheni yendabuko ye-C-reactive kanye nokuhlolwa kwephrotheni ye-C-reactive ephezulu (hs-CRP) yizigaba ezimbili eziyinhloko ezisetshenziswa kwezokwelapha. Nakuba zilinganisa iphrotheni efanayo, izinjongo zazo ziyahlukahluka.

Ukuhlolwa kwephrotheni okujwayelekile kwe-C-reactive kusetshenziselwa ukuxilonga ukuvuvukala okubalulekile okuhlobene nezimo zesikhashana noma zesikhathi eside. Lolu hlobo lokuhlola lusetshenziselwa ukuhlonza nokuqapha ukutheleleka okukhulu kwamagciwane noma amagciwane, izifo ezizimele ezifana ne-rheumatoid arthritis kanye ne-lupus, kanye nokululama ngemva kokuhlinzwa. Lolu hlobo lokuhlolwa kwephrotheni ye-C-reactive luvame ukulinganisa amazinga asukela cishe ku-5 mg/L kuya kumakhulu amaningana mg/L. Amazinga angaphezu kuka-10 mg/L abonisa ukuvuvukala okungaphansi.

Ukuhlolwa kwephrotheni ye-C-reactive ezwela kakhulu kuyinguqulo enembile kakhulu yokuhlolwa kwephrotheni ye-C-reactive ejwayelekile, ekwazi ukubona ngisho namazinga aphansi inguqulo ejwayelekile engase iwaphuthe.

Lokhu kuhlolwa kusetshenziselwa ikakhulukazi ukuhlola ingozi yesikhathi eside yesifo senhliziyo kubantu abaphilile.

Lokhu kuhlola kuthola ukuhlushwa okuncane okuphakathi kuka-0.3 no-10mg/L.

Amazinga engozi yenhliziyo:

• Ingozi ephansi: Ngaphansi kuka-1.0 mg/L
• Ingozi emaphakathi: 1.0 kuya ku-3.0 mg / L
• Ingozi ephezulu: Kukhulu kuno-3.0 mg/L

Ukuqhathaniswa kokuhlolwa kwephrotheni esabelayo kwe-C okujwayelekile kanye nokuhlolwa kwephrotheni esabelayo kwe-C okujwayelekile

Ezinye izinhlobo ezimbalwa ezikhethekile kanye namagama umuntu angahlangana nawo, kuye ngokuthi ilabhorethri noma umongo wezokwelapha, yilezi:

• Ukuhlolwa kwephrotheni esabelayo ye-C ebanzi (i-Wr-CRP): Lokhu ukuhlolwa okusha, okuphelele, okuhlanganisa amakhono okuhlolwa kwephrotheni e-C-reactive okubucayi kakhulu kanye nokujwayelekile. Kungalinganisa ngokunembile amazinga aphansi kakhulu naphezulu kakhulu ephrotheni e-C-reactive ngesikhathi esisodwa, okwenza kube ngcono kakhulu emalabhorethri.
• Ukuhlolwa kweprotheyini esebenzayo yenhliziyo (i-cCRP): Lokhu ngokuyinhloko ukuhlolwa kwephrotheni ye-C-reactive okuzwela kakhulu okusetshenziselwa ukuhlola ingozi yenhliziyo nemithambo yegazi. Nakuba ubuchwepheshe bufana nobo obusetshenziswa ekuhlolweni kwephrotheni ye-hs-C-reactive, ilebula yenhliziyo iqinisekisa ukuhambisana nezindinganiso ezithile zokulawula zokuhlolwa kwempilo yenhliziyo.
• Ukuhlolwa kwephrotheni ye-C-reactive endaweni yokunakekelwa: Lezi zivivinyo ezisheshayo zisetshenziswa emitholampilo naseminyangweni yezimo eziphuthumayo ukuze kutholakale imiphumela ngemizuzu embalwa hhayi ezinsukwini ezimbalwa. Zivame ukusetshenziselwa ukuthola ukuthi ukutheleleka kubangelwa amagciwane noma igciwane, ngaleyo ndlela kusiza odokotela ukuthi banqume ukuthi ama-antibiotic ayadingeka yini.
• Iphrotheni esabela ku-C ezwela kakhulu (ukuhlolwa kwephrotheni esabela ku-us-C): Kwezinye izindawo zocwaningo, i-ultra-sensitive isetshenziswa ngokushintshana nokuhlolwa kwephrotheni ye-C-reactive ene-sensitive ephezulu.

Imiphumela Engemihle Yokuhlolwa Kwamaprotheni Asebenzayo Nge-C:

Ukuhlolwa kwe-C-reactive protein kuyindlela ejwayelekile, enobungozi obuphansi yokukhipha igazi ngokuvamile engabangeli imiphumela emibi kakhulu ngoba idinga ukufakwa kwenaliti kuphela. Noma yikuphi ukungakhululeki kuvame ukuba kuncane futhi kube okwesikhashana.

Iningi labantu liba nezimpawu ezincane endaweni lapho kudonswa khona igazi, okuhlanganisa

• Ubuhlungu obuncane noma ukuhlaba ngesikhathi sokufakwa noma ukususwa kwenaliti.
• Ubuhlungu noma ukuqaqamba engalweni ngokushesha ngemva kwenqubo.
• Ukudumba okuncane noma ukuvuvukala eduze kwendawo yokubhoboza, okuvame ukuphela ezinsukwini ezimbalwa.
• Ukopha okuncane okumayo uma sekufakwe ingcindezi.